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Context— The transcriptional regulation of lipogenesis is a highly coordinated process that is controlled by insulin. Fatty acid synthase (FASN) plays a central role in de novo lipogenesis by converting acetyl-CoA and malonyl-CoA into the final end product, palmitate, which may subsequently be...

Background: Traditional host factors and treatment related metabolic changes are implicated in the increase of impaired glucose levels and Type 2 diabetes mellitus in HIV patients. Diabetes mellitus has specific morbidity and mortality consequences. It also contributes to the burden of other...