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Acute myeloid leukaemia (AML) is a highly malignant clonal hematopoietic disease caused by both inherited and acquired genetic alterations. Current AML classification and prognostic systems incorporate genetic information but are limited to known abnormalities that have previously been identified...

Anaemia affects approximately 1.62 billion people globally corresponding to 24.8% of the world’s population. Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are the most common forms of anaemia. A hormone produced by the liver, hepcidin, is the primary regulator of iron...

Tuberculosis (TB) remains a global public health problem that claims millions of lives every year. The emergence of drug resistant tuberculosis has been recognised as the major threat to the control of TB. The first most important drug resistant TB is the Multi-drug resistant tuberculosis...

Zinc, Copper and Selenium are important trace elements in human health and disease. They play a vital role as cofactors of enzymes such as superoxide dismutase and glutathione peroxide. These act as first line antioxidants enzymes in red blood cells and in plasma. In sickle-cell anaemia patients,...

Introduction: Hepatic tumour is a joint term for a diverse group of liver tumours which are caused by a variety of agents and fall into primary or secondary hepatic tumours. A tumour is an abnormal benign or malignant new growth of tissue that may or may not possess physiological functions and...

Background: The Human Papillomavirus (HPV) has been recently demonstrated to have a negative influence on sperm parameters, fertilization process and abortion rate. Several studies have identified HPV in human semen, mainly from men recruited at fertility or maternity clinics and also in semen...

Context— The transcriptional regulation of lipogenesis is a highly coordinated process that is controlled by insulin. Fatty acid synthase (FASN) plays a central role in de novo lipogenesis by converting acetyl-CoA and malonyl-CoA into the final end product, palmitate, which may subsequently be...

Context: Multiple myeloma (MM) is the second most common blood cancer after lymphomas, thereby accounting for 10% of all haematological malignancies. The incidence of MM is related to age with the condition being more common in the elderly. There is a higher incidence and mortality rate among...

Introduction:Breast cancer remains among the most commonly diagnosed cancers in women. Worldwide, breast cancer comprises 22.9% of all cancers. In Zambia, it is ranked number 2 at 11% after cervical cancer (60%). However, the current prevalence can be reduced through sensitization programmes...

Background: Diabetic nephropathy (DN) is a kidney disease that is a complication of diabetes. Pathogenesis of DN involves damage to the tiniest blood vessels which is followed by increased concentration of blood urea / creatinine and urine albumin excretion. DN is the leading cause of morbidity...