Breast cancer (BC) patients in Zambia more commonly present with advanced-stage disease and often at young ages (≤50 years). Breast cancer gene 1 (BRCA1) is a tumor suppressor gene in which mutations have been linked to disease presentation at a young age. More than 600 distinct pathogenic...
Download PDF ↓The Frequency of Leukaemia types vary in different geographical locations and between age groups and gender. The diagnosis of Leukaemia at UTH is done by Morphological examination of blood or bone marrow smears only. Immunophenotyping is a further diagnostic tool that can be performed to diagnose...
Download PDF ↓The Major Histocompatibility Complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity and is the most polymorphic locus in the mammalian genome. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the...
Download PDF ↓Background: It is approximated that about 50% of malaria infections are asymptomatic in areas where malaria is endemic. In these areas, transmission is intense and consistent over time. As a result, most adults who live in these endemic areas possess partial immunity to malaria due to recurrent...
Download PDF ↓Sickle Cell Disease (SCD) is a chronic incurable genetic blood disorder that affects the Haemoglobin (Hb) within the Red Blood Cell (RBC).The disease affects millions of people throughout the world and is one of the most prevalent and costly genetic disorder. It is also found in people of African...
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