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In the last three decades, Zambia has experienced frequent cholera outbreaks which mainly affect fishing camps around the country and peri urban areas in Copperbelt and Lusaka Provinces where there is unsafe water supply and poor sanitation. In 2009, 2010 and 2016 more than 12000 cases, with...

Breast Cancer gene 1 (BRCA1) and Breast Cancer gene 2 (BRCA2) have gained major scientific interest as potential prognostic and predictive markers for various tumours. Management of breast cancer depends on availability of robust clinical and pathological prognostic and predictive factors to...

Although there are many diagnostic and detection platforms for detection of various bacteria, these often require large elaborate procedures and well trained experts to execute. The turnaround time for results can sometimes be long. The development of portable and low power devices integrated...

BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans and affects over 400 million people worldwide, majority being in Africa. G6PD catalyses the first reaction of the pentose phosphate pathway where it plays a role in generation of NADPH,...

Context— The transcriptional regulation of lipogenesis is a highly coordinated process that is controlled by insulin. Fatty acid synthase (FASN) plays a central role in de novo lipogenesis by converting acetyl-CoA and malonyl-CoA into the final end product, palmitate, which may subsequently be...

The main objective of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to...

Extended Spectrum Beta-Lactamase are enzymes that hydrolyse the beta-lactam ring on most of the beta-lactam antibiotics which comprise of penicillins, cephalosporins, and the monobactam aztreonam thereby rendering the antibiotics ineffective to treatment. These antimicrobial resistant strains...

Methicillin-resistant Staphylococcus aureus is one of the major causes of nosocomial infections worldwide. It is endemic in hospitals and prevalent in the community and amongst livestock. Morbidity and mortality amongst patients with Methicillin-resistant Staphylococcus aureus infections are high...

Salmonellaenterica species are important food-borne pathogens that cause gastroenteritis and enteric fever, and are responsible for a huge global burden of morbidity and mortality. In addition, Salmonellaenterica has been associated with multiple drug resistance and this complicates disease...

Background: The bark root of Steganotaenia araliacea Hochst (Umbelliferae) nicknamed “herbal pitocin” is used in the traditional circles in Zambia to induce and/or enhance labour. This work was aimed at investigating the contractile stimulatory effects of the aqueous extracts of Steganotaenia...