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Acute myeloid leukaemia (AML) is a highly malignant clonal hematopoietic disease caused by both inherited and acquired genetic alterations. Current AML classification and prognostic systems incorporate genetic information but are limited to known abnormalities that have previously been identified...

The detection of ischemia prior to infarction is a challenging concept. Studies have shown Ischemia Modified Albumin (IMA) to be a sensitive marker of ischemia, and it has been suggested that IMA could be an early marker to help detect ischemic stroke and ruling out patients with acute coronary...

Anaemia affects approximately 1.62 billion people globally corresponding to 24.8% of the world’s population. Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are the most common forms of anaemia. A hormone produced by the liver, hepcidin, is the primary regulator of iron...

Tuberculosis (TB) remains a global public health problem that claims millions of lives every year. The emergence of drug resistant tuberculosis has been recognised as the major threat to the control of TB. The first most important drug resistant TB is the Multi-drug resistant tuberculosis...

Zinc, Copper and Selenium are important trace elements in human health and disease. They play a vital role as cofactors of enzymes such as superoxide dismutase and glutathione peroxide. These act as first line antioxidants enzymes in red blood cells and in plasma. In sickle-cell anaemia patients,...

Introduction: Hepatic tumour is a joint term for a diverse group of liver tumours which are caused by a variety of agents and fall into primary or secondary hepatic tumours. A tumour is an abnormal benign or malignant new growth of tissue that may or may not possess physiological functions and...

Spontaneous abortion in Zambia is defined as non-induced embryonic death or passage of products of conception before 28 weeks’ gestation. Placental insufficiency as a result of thrombi lodging in the uteroplacental bed is considered to be a cause of pregnancy loss. Circulating microparticles are...

Vitamin B12 and folate deficiency is a well-known health problem. Deficiencies of folic acid and vitamin B12 are known to cause megaloblastic anaemia, which is characterised by presence of abnormally large erythrocyte precursor cells, megaloblasts, in the bone marrow and macrocytic red cells in...

Background: It is approximated that about 50% of malaria infections are asymptomatic in areas where malaria is endemic. In these areas, transmission is intense and consistent over time. As a result, most adults who live in these endemic areas possess partial immunity to malaria due to recurrent...

Background: The Human Papillomavirus (HPV) has been recently demonstrated to have a negative influence on sperm parameters, fertilization process and abortion rate. Several studies have identified HPV in human semen, mainly from men recruited at fertility or maternity clinics and also in semen...