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Context - A number of biomarkers are implicated in the pathophysiology of hypertension. Low adiponectin levels have been associated with hypertension and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and...

thrombogenic marker d-dimer are strongly associated with a higher mortality risk in patients with HIV infection. Aims – The aim of the study was to determine if D-Dimer levels in conjunction with IL 6 levels, as markers of predisposition to thrombosis, are higher in HIV positive than in HIV...

Context— The transcriptional regulation of lipogenesis is a highly coordinated process that is controlled by insulin. Fatty acid synthase (FASN) plays a central role in de novo lipogenesis by converting acetyl-CoA and malonyl-CoA into the final end product, palmitate, which may subsequently be...

Background: The pathogenesis of human hypertension is complex and multifactorial. Haptoglobin genes have been cited as risk factors in the development of hypertension. Haptoglobin is an α2-glycoprotein acute phase reactant that binds to free haemoglobin and forms a stoichiometrically stable...

Context: Multiple myeloma (MM) is the second most common blood cancer after lymphomas, thereby accounting for 10% of all haematological malignancies. The incidence of MM is related to age with the condition being more common in the elderly. There is a higher incidence and mortality rate among...

Background Human papilloma virus (HPV) has been associated to conjunctival squamous cell carcinoma (CSCC) and has been documented in studies originating from different parts of the world. In Zambia, eye cancers are on the increase and between 2005 and 2009 they were ranked number three (3) among...

Introduction:Breast cancer remains among the most commonly diagnosed cancers in women. Worldwide, breast cancer comprises 22.9% of all cancers. In Zambia, it is ranked number 2 at 11% after cervical cancer (60%). However, the current prevalence can be reduced through sensitization programmes...

Title: Serum levels of Lipoprotein(a) in HIV positive patients on HAART at Livingstone General Hospital, Livingstone, Southern Province, Zambia. Background: Lipoprotein(a) (Lp(a)) is a highly atherogenic independent risk marker for Cardiovascular disease (CVD) and current studies have shown that...

Background: Diabetic nephropathy (DN) is a kidney disease that is a complication of diabetes. Pathogenesis of DN involves damage to the tiniest blood vessels which is followed by increased concentration of blood urea / creatinine and urine albumin excretion. DN is the leading cause of morbidity...

Background: Patients with diabetes mellitus have a high risk of atherothrombotic events. Eighty percent of patients with diabetes mellitus die due to thrombosis, and 75% of these deaths are due to cardiovascular complications. A cross-sectional analytical study was conducted at Ndola Central...