Acute myeloid leukaemia (AML) is a highly malignant clonal hematopoietic disease caused by both inherited and acquired genetic alterations. Current AML classification and prognostic systems incorporate genetic information but are limited to known abnormalities that have previously been identified...
Download PDF ↓Anaemia affects approximately 1.62 billion people globally corresponding to 24.8% of the world’s population. Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are the most common forms of anaemia. A hormone produced by the liver, hepcidin, is the primary regulator of iron...
Download PDF ↓Chronic MyeloidLeukaemia (CML) is consistently associated with a characteristic chromosome translocation called the Philadelphia (Ph) chromosome. This translocation fuses sequences of theBreakpoint Cluster Region(BCR) gene from band q11 on chromosome 22 with regions of theAbelson(ABL) gene from...
Download PDF ↓von Willebrand Disease (vWD) is the most common or prevalent inherited bleeding disorder. It is caused by a deficiency or dysfunction of von Willebrand Factor, which is a glycoprotein that carries Factor VIII (Anti haemophilic factor) and an adhesive protein in platelet-vessel wall interactions....
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